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Tell sufferers that: Tramadol Hydrochloride Prolonged-Release is for oral use only and may be swallowed total. The capsule should not be chewed, dissolved, crushed or break up. Tramadol Hydrochloride Extended-Release may well trigger seizures and/or serotonin syndrome with concomitant utilization of serotonergic brokers (which include SRIs, NRIs, a